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Building global health with lego vaccines

Prof Tuck Seng Wong and Dr Kang Lan Tee from the University of Sheffield, explain building global health with LEGO vaccines.
FIGURE 1 The gap in research paradigms: turning evidence into relatable narratives.

Beyond the numbers: COVID-19 data miscommunication

Prof Giampiero Favato and Cristina Oliva, MD, explain how storytelling shapes health behaviours beyond the numbers. Here, we learn lessons from COVID-19 data miscommunication.
Figure 1. Two routes of brain infection by which SARS-CoV-2 may enter the hypothalamus and infect GnRH neurons. The virus attaches to and enters cells harbouring surface receptors such as ACE2 (black spanner-like symbol) or NRP1 (red cylinder). GnRH neurons exhibit both, which might increase their vulnerability. A. The haematological route, whereby the respiratory virus (white spheres) makes its way through the lungs into the bloodstream (dark red), and thence into the median eminence (ME), a part of the hypothalamus that harbours ”fenestrated” or leaky blood vessels. The virus may affect a number of different cell types locally, including GnRH neurons (green), whose secretory terminals approach the fenestrated vessels, and tanycytes (grey), whose processes control this secretion and also transport other bloodborne hormones and other substances into the brain. Once inside the brain ventricles (V), fluid-filled canals within the brain, the virus can also travel to other areas. B. The olfactory route, whereby the virus enters the olfactory bulb (OB) of the brain directly from the nose across the bony cribriform plate by means of nerve bundles or infected olfactory neurons and other cell types. GnRH neurons, which are born in the nasal epithelium during the embryonic period and migrate into the brain along these nerve bundles to their final positions, still maintain a connection with their birthplace, and could be thus be infected directly or indirectly through olfactory neurons or other cells. GnRH neurons also project to parts of the brain involved in higher functions such as cognition, potentially contributing to long-COVID symptoms such as “brain fog”.

Brain infection by SARS-CoV-2: Lifelong consequences

The WATCH team, founded to elucidate the role played by specialized brain cells called tanycytes in various physiological processes, has been investigating how and where the SARS-CoV-2 virus infects the brain, and some long-term consequences of this neuro-invasion.
closeup of a young man in an office holding a briefcase and a surgical mask in his hand

Stress and coping during COVID-19

Marian Adriaansen and Henk Poppen from HAN University of Applied Sciences discuss their research on how Bachelor’s students in nursing coped with the impact of the COVID-19 pandemic.
close up of sewage drain.

Wastewater surveillance for infectious disease preparedness

The University of Oklahoma Wastewater Based Epidemiology (OU WBE) team highlights successes from their three years of wastewater surveillance in Oklahoma & how this surveillance approach can be used as next-level monitoring for infectious disease preparedness.
Beautiful young woman riding on the metro wearing a facemask to avoid an infectious disease - COVID-19 lifestyle concepts

Post-pandemic MERS-CoV still presents risks

Darryl Falzarano, Research Scientist at the Vaccine and Infectious Disease Organization (VIDO), discusses potential solutions that are needed to tackle the coronavirus known as MERS-CoV.
Petri dish with close up colourful detailed bubbles on a white background. Marco shot with a white backlight.

Drug repositioning without the gene expression of disease cells treated with drugs

Y-h. Taguchi, Professor at the Department of Physics, Chuo University in Japan, provides comments on drug repositioning without the gene expression of disease cells treated with various drugs.

What has been the impact of Brexit on the UK economy?

Sarah Hall, University of Nottingham, discusses and assesses the impact of Brexit on the UK economy, in combination with COVID-19 and the Ukraine war.
Two friends sitting outside a store that promotes sustainable living in the North East of England. The store has refill stations to reduce plastic and food waste. The store sells homemade organic bars of soap as well as vegan based foods.

What is the importance of friendship and mental health in pandemics?

Terence j Ryan, from the University of Oxford, explores the importance of friendship and mental health in relation to pandemics and immunity.
The mid adult female surgeon goes out to the waiting room to ask the young adult woman for information about the patient.

Acute care hospital reform in Japan: Outcomes in quality and market competition

This paper describes why the fee system for acute care hospital reform in Japan is beginning to show results.
Tired businessman in complex network of lines. 3D generated image, crisis communication

The IDEA Model: A best practice for data-driven strategic risk and crisis communication

Professors of Strategic Communication Dr. Deanna D. Sellnow and Dr. Timothy L. Sellnow explore strategic risk and crisis communication using the IDEA Model, a theoretically grounded tool for effective communication.
Firemen using broom to clean street corner from debris after car accident during winter day in Quebec city. Fire truck behind and police officer passing by

Workers at risk: How do traumatic jobs affect essential workers?

R. Nicholas Carleton and Gregory S Anderson analyse the workplace stressors and risks of public safety personnel and front-line healthcare workers.
Virus in dirty dust smoke flow in the air Covid- virus 3D rendering - nanotechnology

How entrepreneurship and industry saved COVID fighting nanotechnology?

Here Thomas J. Webster, Ph.D. explores how Nanotechnology was crucial in the battle against COVID-19 and how entrepreneurship helped it thrive.
woman in COVID mask

Long Covid lessons: beyond winter and the COVID pandemic

Paying attention to Long Covid lessons is key: Long Covid has already provided lessons for other long-term conditions and planning for future pandemics far beyond COVID-19.
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Open Science and Research Infrastructures provide the foundation and pillars necessary to tackle global...

COVID has highlighted the importance of Open Science and research infrastructures to accelerate the impact of scientific research.
Virus cells or bacterias under microscope lens

Slight changes can improve much for algorithms looking at gene expressions

Y-h. Taguchi, a Professor at Chuo University, looks at the slight changes made to algorithms when looking at the COVID-19 virus and gene expressions.

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