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Alternative flipon conformations compared to Watson and Crick DNA are displayed in the left panel. Flipons offer a new way to program the genome

RNA and DNA flipons in health and disease

Flipons are the next step in DNA research. What they are, their role in DNA and RNA coding, their impact on medical science, and their relation to the immune system are discussed here.
DNA sequencing gel run science and data genomic genetic analysis background abstract pattern.

Understanding thermolabile protecting groups for nucleic acid-based drugs

Serge L. Beaucage investigates thermolabile protecting groups for the amine functions of purine and pyrimidine deoxyribonucleosides for the development and implementation of synthetic DNA sequences as nucleic acid-based drugs.
molecular structure digital concept

The idea of self-organisation in biology and its critics

Using the example of Alan Turing’s paper on morphogenesis, Ute Deichmann at Ben-Gurion University of the Negev explores self-organisation in biology.
Bacteria and viruses illustration

Shrouded in genomic heterochromatin are ancient viral-like elements that could jump

Host defences operate to prevent ‘ancient viruses’ from ever jumping but, in cancers, cells lose multiple layers of ‘epigenetic’ control, and this can lead to the awakening of jumping or ‘retrotransposition’ of ancient viruses.
doctor worried about research

Information overload and the ossification of immunological research

Peter Bretscher, Faculty in the Department of Biochemistry, Microbiology and Immunology at the University of Saskatchewan questions whether there is a way of fostering resilience in immunological research.
Global image

Open Science and Research Infrastructures provide the foundation and pillars necessary to tackle global...

COVID has highlighted the importance of Open Science and research infrastructures to accelerate the impact of scientific research.
sunburn on a man

Part 4: Scientific sunburn & skin cancer

In this last of a four part series, Chanda Siddoo-Atwal, President and Primary Biochemist of Moondust Cosmetics Ltd, explores the potential of the plant compound, resveratrol, as a cancer chemopreventive agent in the context of sunburn & skin cancer.
chromosome cells

Satellite DNA arrays barcode chromosomes to regulate genes

In this piece, Dr Helen Rowe summarizes how arrays or strings of multi-copy satellite DNAs can barcode chromosomes to regulate cell fate, by acting...
Long structure of the DNA double helix in depth of view.

What are the possibilities of DNA and RNA sequences?

Serge L. Beaucage, Supervisory Research Chemist at the Food and Drug Administration discusses his work with DNA and RNA sequences and the groundbreaking impact this technique could have.

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