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Progress in development of disease-modifying treatments in Parkinson’s Disease
Henri Huttunen, Chief Scientific Officer, Herantis Pharma Plc, charts progress in the development of disease-modifying treatments for Parkinson’s disease.
The function of fingerprints: How can we grip?
Professor Gun-Sik Park, in the Department of Physics and Astronomy at Seoul National University explores the function of fingerprints from a lens of understanding the mechanism of our human ability to grip.
The link between gene expression and machine learning
Professor Y-h. Taguchi uses tensor decomposition to identify genes associated with altered gene expression caused by drug treatment.
Genetic coding: Roots of genetic readout in nucleic acid structural duality
Charles W. Carter, Jr, from the Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill explores the roots of genetic readout in the inherent structural duality of DNA and how genetic coding expanded its potential, enabling life to emerge.
PopART: Universal testing and treatment to stop HIV spread
Here, Professor of Epidemiology & International Health Richard Hayes explores and details the PopART study and other trials of Universal Testing and Treatment, a promising strategy to reduce HIV spread.
Kernel Tensor Decomposition can improve the drug discovery process
Kernel tensor decomposition and its use in drug discovery for SARS-CoV-2 was vital, however, due to its general method, it has the potential to be used for a wide range of future problems.
The haplogroup gap: The ticking time bomb of cardiometabolic disease in developing nations
Cardiometabolic disease (CMD) refers to a cluster of inter-related factors, including obesity, high blood pressure, high blood sugar, and elevated cholesterol (1).
Global food security – Part 4; Enhancing a struggling food system
Professor Curtis R Youngs, the M.E. Ensminger Endowed Chair of International Animal Agriculture at Iowa State University, analyses the flaws of the food system in his fourth part analysis of global food security.
Genetics and machine learning can improve blood transfusion outcomes
Better blood transfusion outcomes for patients and better protection of the NHS blood supply can be achieved with machine learning, argue Drs Samuel McDermott, Nicholas Gleadall and Sara Trompeter.
Shrouded in genomic heterochromatin are ancient viral-like elements that could jump
Host defences operate to prevent ‘ancient viruses’ from ever jumping but, in cancers, cells lose multiple layers of ‘epigenetic’ control, and this can lead to the awakening of jumping or ‘retrotransposition’ of ancient viruses.
Understanding Hydra Regeneration
Here, Charisios Tsiairis from Friedrich Miescher Institute for Biomedical Research explores Hydra Regeneration and the genetic programs that make it possible.
Killing cancer softly: The resolution of cancer lies in tumor cells
Dr Dipak Panigrahy, M.D., an Assistant Professor at Harvard Medical School looks at killing tumor cells to resolve the cancer epidemic.
Genomic instability and nuclear architecture in cancer
Sabine Mai and Aline Rangel-Pozzo, at the CancerCare Manitoba Research Institute and The University of Manitoba, Winnipeg, Canada, discuss genomic instability in relation to 3D spatial organisation of telomeres.
Mendel, Darwin, and Lysenko: the battle toward understanding genetics
August 1948 saw the Soviet government ban all teaching and research in genetics. Within a year, “the doctrine of agronomist Trofim Lysenko – dubbed ‘Soviet Creative Darwinism’ – replaced genetics in curricula and research plans of biological, medical, veterinary, and agricultural institutions.” (Krementsov 2010).
Stem cell-based therapy for corals
Could medical approaches of stem cell-based therapy, be a tool for corals’ resilience to heat stress? Benyamin Rosental, Principal Investigator, Assistant Professor at Ben Gurion University of the Negev in Israel answers the compelling question here.
Preventing autoimmune diabetes in genetically susceptible people
Department of Biochemistry - Microbiology and Immunology - University of SaskatchewanCan we now envisage antigen-specific therapies to prevent and treat organ-specific autoimmune diseases, such as autoimmune diabetes?
Slight changes can improve much for algorithms looking at gene expressions
Y-h. Taguchi, a Professor at Chuo University, looks at the slight changes made to algorithms when looking at the COVID-19 virus and gene expressions.
Identifying adult-onset type 1 diabetes
Liping Yu, at the Barbara Davis Center for Diabetes, highlights how we can recognise and diagnose adult-onset type 1 diabetes.
Satellite DNA arrays barcode chromosomes to regulate genes
In this piece, Dr Helen Rowe summarizes how arrays or strings of multi-copy satellite DNAs can barcode chromosomes to regulate cell fate, by acting...
What are the possibilities of DNA and RNA sequences?
Serge L. Beaucage, Supervisory Research Chemist at the Food and Drug Administration discusses his work with DNA and RNA sequences and the groundbreaking impact this technique could have.