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Cinchona (Cinchona officinalis). Called Fever tree also

A legacy of medicine and biodiversity: Protecting the cinchona tree

The endangered Cinchona officinalis, native to the Andean foothills, produced the world’s first anti-malarial drug. Augusta Cueva-Agila explains why it is crucial to conserve this species and how conservation efforts can be implemented.
Figure 1. Comparison of prediction models in A) two-dimensional (2D) and B) three-dimensional (3D) analyses. The 2D model demonstrates a poor-fitting linear relationship constrained by limited variables. In contrast, the 3D model incorporates an additional dimension, providing a better fit and improved predictive accuracy. This highlights how multi-dimensional analysis, such as those enabled by machine learning, can uncover more complex relationships within heterogeneous clinical and biological data.

Predicting cochlear implant performance: Moving beyond single biomarkers and leveraging artificial intelligence

Matthew Shew, Amit Walia, and Craig A. Buchman highlight that the significant variability in speech perception among cochlear implant users can be addressed by using a multi- faceted approach that incorporates emerging technologies like machine learning and artificial intelligence to improve outcome prediction models.
Neuroengineering with engineered endosymbionts: Schematic of plan to use engineered endosymbionts for guided induction of dopaminergic neurons from astrocytes or neural stem cells in a Parkinson’s disease mouse model—external signal for control could be chemical or magnetothermal.

Neuroengineering with engineered endosymbionts

Christopher H. Contag and Ahmed A. Zarea from Michigan State University’s Institute for Quantitative Health Science and Engineering explore therapeutic approaches to neurodegenerative diseases using a novel strategy based on engineered endosymbionts systems that could revolutionize patient care.

The role of host condition and environment on infection outcome

Brian P. Lazzaro from Cornell University discusses his research on the factors influencing immune response and infection outcome, drawing on powerful experimental systems, such as Drosophila melanogaster as a model host, to gain a deeper understanding of foundational biological processes.
Team of Medical Research Scientists Conduct Experiments with Help of Microscope, Test Tubes, Micropipette and Desktop Computer. Modern Biological Applied Science Laboratory with Diverse Colleagues.

Exposomics: A shift in biomedical research with potential to improve human health

Recent advances in exposomics offer an exciting opportunity to comprehensively catalog human exposures and link them to biological responses determining health and disease. Pamela J. Lein, Ph.D. from the University of California, tells us more.
Bilayer Lipid Membrane - 3d rendered image of Cell Membrane Phospholipid Structure, Phospholipid bilayer of the cell membrane. Abstract medical illustration. Microscopic view. Microbiologic research concept.

Cell biology research: The mystery of cholesterol homeostasis

Kazumitsu Ueda, PhD from Kyoto University, WPI-iCeMS, unveils the mystery of cholesterol homeostasis in this cell biology research focus.
Jasper National Park in Alberta Canada

Helping biodiversity conservation with modelling

Professor Guillaume Blanchet from Université de Sherbrooke discusses how modelling can aid in the conservation of biodiversity.

Primate exposure to anthropogenic pollutants: An overlooked conservation concern

Michael Wasserman of Indiana University discusses research on wild primate exposure to endocrine disruptors, such as pesticides, flame retardants, and phytoestrogens.
3d illustration of clostridium bacteria

An ancient therapy modernized for Clostridioides Difficile therapy

Clostridioides difficile is a type of bacteria that often affects people who have been taking antibiotics. Glenn S. Tillotson of GST Micro LLC explains how live biotherapeutic products have shown promise as a safe and effective treatment to help restore the normal gut microbiome.
Figure 1: Ratios of the concentrations of Sodium ions [Na+] and Potassium ions [K+] in water on land and in the sea vs in living cells and in blood.

Is there an elephant in the room of research on the origins of life?

Helen Greenwood Hansma, from the University of California at Santa Barbara, questions if there is an elephant in the room of research when it comes to the origins of life.
Training and citizen engagement to tackle soil health challenges

Training and citizen engagement to tackle soil health challenges

The ECHO project approach in tackling soil health challenges through soil literacy and citizen engagement.

Asbestos, the pleural cavity, and autoimmune disease

Jean C. Pfau, Ph.D. from the Center for Asbestos-Related Disease and Kinta Serve from Idaho State University, provide their perspective on asbestos, the pleural cavity, and autoimmune disease.
Endoscopic view of flowing red blood cells in a vein, illustration render

Ciliary biomarkers for vascular health

Ramani Ramchandran, Professor at the Medical College of Wisconsin, investigates ciliary biomarkers for diagnosing and prognosing vascular health.

Data integration: A key to understanding the biological basis of mental disorders

ses two key advancements in genome-wide association studies (GWAS) and gene expression data to better understand the biological basis of mental disorders.
Shigella dysenteriae bacteria - 3d rendered illustration

Membrane biogenesis, nutrient transport, and natural health product characterization

Find out here about Dr. Bakovic, an internationally recognized researcher in membrane biogenesis, nutrient transport, and natural health product characterization.
Fig. 1. Interactive Emergence Society vs. T-society

Understanding T-societies: How patterns shape our lives

Emeritus Professor Magnus S Magnusson explores the unique sudden bio-mathematical self-similarity between human and protein societies and the human explosion: from T-patterns to T-strings and T-societies.

E. coli genomes, big data, and messy biology

Here, David Ussery from the Department of BioMedical Informatics, UAMS, details E. coli genome diversity, big data, and messy biology. New methods, we discover, allow for the comparison of millions of bacterial genomes in a few days and the confident assignment of taxonomic clusters.
Graphic representation of outcomes derived from the application of microbes.

SUS-MIRRI.IT: How microbial culture collections hold up a more sustainable, competitive, and resilient bioeconomy

Marino Moretti and Giovanna Cristina Varese, Project Manager and Scientific Coordinator, respectively, of the EU-funded project SUS-MIRRI.IT, on behalf of all project partners, explain how safeguarding microbial biodiversity is extremely paramount for the future of our planet.
Figure 1. Visualization of direct and mediated extracellular electron transfer by bacteria.

Microbial extracellular electron transfer in the human gastrointestinal tract

Gratian Ting and Arpita Bose from Washington University in St. Louis discuss the fascinating role that extracellular electron transfer plays within the human gut.
Petri dish with close up colourful detailed bubbles on a white background. Marco shot with a white backlight. mechanical energy

Mechanical energy at the origins of life

Did mechanical energy power life’s origins before chemical energy such as ATP was available?

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