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Reconstructed skeleton of a 2.1-m-tall giant ground sloth, Megalonyx jeffersonii from Holmes County, Ohio, US, mounted in 1896 (A); a 25-cm-long claw core from the right rear foot (B); and detail of the upper part of the right femur showing slices presumably made using a flint knife by a North American Palaeo-Indian approximately 13,100 years ago (C).

A gentle giant: Thomas Jefferson’s ground sloth

Professor Loren E. Babcock and Dr H. Gregory McDonald discuss the historical significance of palaeontology, focusing on key figures’ contributions to the field and their studies of the ground sloth, Megalonyx.
Seniors lifestyle. Copy space. Outdoors activities.

The next chapter in regenerative medicine for osteoarthritis: From real-world evidence to regulatory shifts

Osteoarthritis (OA) remains one of the leading causes of disability worldwide, yet the therapeutic landscape is evolving faster than ever.
RNA therapeutics target many diseases through well-understood biological pathways.

The oncoming tsunami of RNA therapeutics

Alan Herbert, Founder and President of InsideOutBio, discusses the significant advancements in RNA therapeutics, highlighting their role in supporting public health and their transformative potential in modern medicine, particularly for addressing genetic conditions and cancer.
Blur background of sphere network structure. Connection abstract design.

Enabling preventive medicine and improving patient care via aptamer-based molecular monitors

As health systems put greater focus on preventive, personalized care, Netzahualcóyotl Arroyo-Currás tells us about the broad benefits of Continuous Molecular Monitors (CMMs) in providing insights into biomolecular markers that facilitate early disease detection.
DNA

Deconstructing misconceptions: The relevance of androgens for human health

Alexandra Cara and Carol F. Elias from the University of Michigan Medical School provide insights into the critical role of androgens in human health, including their vital roles throughout various life stages.
digital concept

Unravelling NASH and insulin resistance: Insights from the department of human health and nutritional...

Open Access Government sits down with a researcher from the Department of Human Health and Nutritional Sciences to discuss their groundbreaking work on nonalcoholic steatohepatitis (NASH) and insulin resistance. Their research delves into the molecular underpinnings of these increasingly prevalent conditions, offering new avenues for understanding, prevention, and treatment.
I used a slide 35mm film !The fiber of asbestos seems like a cotton fiber but it is not soft.

Asbestos: Early immune responses

Ujjwal Adhikari, Kinta Serve, and Jean Pfau explain how asbestos exposure negatively affects the body’s immune response and repair mechanisms, particularly through macrophage dysfunction. They emphasize that gaining a better understanding of cellular responses to inhaled particles could help researchers discover new therapeutic strategies for addressing environmentally induced conditions.
salmonella bacteria 3d illustration

Using machine learning to predict the severity of salmonella infection

David Ussery, a Professor in the Department of BioMedical Informatics at UAMS, and his student, Aakash Bhattacharyya, discuss using Machine Learning methods to predict the pathogenicity of a bacterial infection based on genome sequencing.
Figure 1. Historical Ontario white navy bean yields.

Bean breeding at the University of Guelph: Past and present

Examine bean breeding at the University of Guelph, both past and present, conducted by its Department of Plant Agriculture.
Left, intact epithelium is a continuous sheet with an electrical potential across it, and signal molecules produced on one side (green) that cannot reach receptors (yellow) on the other side. A basement membrane (grey) separates epithelium from other cells. When the sheet is broken, as in a wound, cells change shape (‘EMT’) and send signals that include electric currents and interaction between signal molecules and receptors. The basement membrane may be breached, bringing epithelial cells in contact with other cells. Defence and repair cells (blue) respond. Right, in cancers, the epithelial sheet is disrupted, activating the same wound-healing changes.

Cancers are like wounds because they are damaged tissue

Cancers resemble wounds. The question is why, and what does this mean? Many features of cancers – the so-called ‘Hallmarks of Cancer’ – may be mostly a wound-healing response. Dr Paul Edwards, Emeritus Reader at the University of Cambridge explores.
Doctor with human thyroid anatomy model. Thyroid tumor and cancer, postpartum period, papillary carcinoma and health

Rethinking papillary thyroid cancer: Why “low risk” isn’t always low impact

Oliver Bathe, Professor of Surgery and Oncology at the University of Calgary and CEO of Qualisure Diagnostics, urges us to rethink papillary thyroid cancer, noting that “low risk” isn’t always synonymous with low impact.
X-ray image of shoulder

Regenerative medicine and osteoarthritis: SVF, exosomes and beyond

Torbjörn Ogéus from Stockholms Led- & Smärtspecialist guides us through the evolving science of stromal vascular fraction, exosomes, and beyond in regenerative medicine and osteoarthritis.
Figure 1. Proposed method for creating a holobiont from engineered minimal genome endosymbionts (derived from JCVI-Syn3B) that regenerate progenitor cells in liver tissue. Fluorescently labeled endosymbiont chassis bacteria with a cationic lipid coating (1) pick up protein coronas comprised of blood peptides as they traffic to the liver (2). The labeled bacteria can be visualized in the tissue (3). Once inside the host cells, the engineered endosymbionts secrete transcription factors that affect the genetic circuits of the cell (4), with limited replication with the host cytoplasm (5). After sustained reprogramming by the secreted transcription factors, the function of the holobiont is redirected (6) toward progenitor cells that can regenerate damaged liver tissue (7). Figure created using Biorender.

Tracing evolution’s blueprint: Minimal genome life and the engineering of synthetic endosymbiosis

Roksana Riddle and Christopher H. Contag from Michigan State University discuss the concept of endosymbiosis, how it has evolved, and present strategies to engineering endosymbionts and their applications in developing innovative therapies.
Unrecognizable pharma research scientist selecting the only set of drugs personalized by genome sequencing in a lineup of pills and tablets. Healthcare concept for pharmacogenomics, pharmacogenetics.

CYP genes and haplotypes in personalised medicine

Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, focuses here on CYP genes, haplotypes, and their applications in personalised medicine.
Figure 1: Flipons to Learn By: Each Shape Encodes Information Differently and has a different probability of flipping from one conformation to another.

Training your genome

Founder and President of InsideOutBio, Alan Herbert, explores the evolving understanding of genome information storage, and the significance of repetitive sequences called flipons in genome training. These flipons can alter their shape without breaking DNA and are vital in cell biology, especially in responding to environmental stress.
Figure 1: Therapeutic relevance of GPCRs in various diseases.

AI-driven innovations in GPCR ligand synthesis for treating inflammatory diseases

This article explores the significance of G Protein-Coupled Receptors (GPCRs) in therapeutic drug development and strategies for advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased agonism, and allosteric modulators.
Biology nerve cell with biomedicine concept, 3d rendering. 3D illustration.

Unlocking the brain: Pioneering psychiatric genomics at the University of Arizona

Psychiatric disorders challenge us deeply. At the University of Arizona, researchers dissect their molecular roots, focusing on genomics. They aim to decode miRNA’s role in conditions like depression, using advanced analysis to forge a path towards personalized mental health care. Find out more in this exclusive Q&A.
close up of 3d microscopic blue bacteria

Microbiomes should be incorporated into The One Health Joint Plan of Action

The One Health Joint Plan of Action was created by major international organizations to tackle global health issues related to human, animal, plant, and environmental health. This article emphasizes the importance of integrating microbiomes into this framework to enhance health systems and prevention strategies.
abs Bacteria concept - 3d rendered microbiology image. Medical research, health-care concept.

Bioinformatics into TB surveillance: A new approach to an ancient foe

David Ussery, a Professor in the Department of BioMedical Informatics at UAMS, and his Ph.D. student Brian Delavan discuss bioinformatics into TB surveillance, presenting a new approach to tackling this ancient foe.
Concept. 3D Render

Stem cell exhaustion and its role in healthy aging

Scientist Sarallah Rezazadeh from the Icahn School of Medicine explores the molecular mechanisms behind adult stem cells as we age.
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