Dr. Martin, PhD, is a Professor in the Department of Pathology, Division of Neuropathology, Department of Neuroscience, and Department of Anaesthesiology & Critical Care Medicine at Johns Hopkins University School of Medicine. He is an experimental neuropathologist-neurobiologist with expertise neuroanatomy, cell biology, biochemistry, epigenetics, and numerous animal and cell model systems of neurodegeneration, including human induced pluripotent stem cell (iPSC) derived cortical neurons and oligodendrocytes.
For >25 years, Dr. Martin’s research has focused on brain and spinal cord neuroanatomy and neuropathology and mechanisms of neurodegeneration in human CNS disease and acquired brain injury, including Parkinson’s disease, ALS, and Alzheimer’s disease, hypoxic-ischemic encephalopathy. To understand the mechanism of neurodegeneration he has used many different animal (small and large) and cell culture models, including neuronal death caused by chemical warfare agents, excitotoxicity, DNA damage, cerebral ischemia, axotomy/target deprivation, mitochondrial perturbations, and human gene mutations. He was a recipient of an NIA Leadership & Excellence in Alzheimer’s Disease (LEAD) award for his work on glutamate receptors, excitotoxicity & neuronal cell death. During this work, he became the first to describe the concept of the cell death continuum in the injured and degenerating nervous system and the potential role of the mitochondrial permeability pore as a driver in neuropathological processes.
Dr. Martin currently has an h-index of 95 and 37,891 citations (Google Scholar).
