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Figure 1: Graphical representation of pharmacokinetic processes. Botanicals taken concurrently with drugs may modify any of these processes.

Understanding botanical-drug interactions

With a specific focus on pharmacokinetic and pharmacodynamic mechanisms, Dr Erin C Berthold discusses the interactions between botanical and herbal supplements and conventional pharmaceuticals, highlighting the urgent need to examine these interactions for public health and patient safety.
image: ©Politecnico di Milano – Italy

Materials and structures that interpret signals and react

Alberto Corigliano, a Full Professor at the Politecnico di Milano, explores the development of sentient materials and structures through the IMMENSE project.
DNA abstract digital visualization. Changes in the genome, scientific transformations

The legacy of bias: Building the foundation for sex and gender-based medicine

Alyson J. McGregor, Associate Dean at the University of South Carolina School of Medicine, highlights the historical bias present in medical research; the exclusion of which has created a significant knowledge gap that impacts the diagnosis and treatment of various health conditions.
Atomic Force Microscope in Material Research Laboratory.

Atomic-Force Microscopy (AFM) data: Are these images real?

Focusing on atomic-force microscopy (AFM) data, Nancy A. Burnham examines the challenges in image processing for scientific research, highlighting how different techniques yield varied images and clearer views of key features. The choices researchers make during processing can therefore lead to differing conclusions, underscoring the importance of critical evaluation in scientific publications.
Figure 1. Human oligodendrocytes. A. Cartoon of oligodendrocyte myelination of neuronal axons. B-D. Oligodendrocytes grown in a dish (cell culture). E,F. Oligodendrocyte excitotoxicity. G. Peroxynitrite (ONOO) formation and protein damage. H. Oligodendrocyte excitotoxicity with quinolinic acid (QA) causes formation of toxic forms of α-synuclein as monomer (arrow) and oligomers. Ponceau shows equal protein loading in the lanes.

iPSCs and NSCs model newborn brain injury

This article discusses research by Dr. Lee J. Martin and his team on HIE, a leading cause of neonatal mortality. They use human induced pluripotent stem cells (iPSCs) and neural stem cells (NSCs) and emphasize the vulnerability of oligodendrocytes, sharing how these cells can accumulate toxic misfolded proteins, potentially causing severe neural damage and long-term cognitive disabilities in affected infants.
Adorable little girl holding her mother hand. Striped t-shirt worn by little girl. Iron bars in the background.

The effects of parental imprisonment on children’s education and health

Written by Egil Kjerstad, Research Director at the NORCE Norwegian Research Centre, this article discusses a research project aimed at understanding how parental imprisonment affects children’s education and health.
Multicolored flowing data like a river with stones, ESG, green technology, sustainability and responsible business concepts, 3d render.

Rare earth, critical minerals, and bio-molecules: Centering African IPLCs in the new resource economy

Dr. Metolo Foyet, Conservation Equity & Safeguards Specialist at The Nature Conservancy, highlights the intersections of critical minerals, biodiversity, and Indigenous rights in the global green transition.
Selective focus shot of mid adult female therapist giving constructive advice to insecure teenage boy, that is struggling with negative emotions, sitting across from her on the sofa, during a therapy session.

Youth suicide: An overview

Professor Deborah Winders Davis from the University of Louisville School of Medicine discusses the prevalence, risk factors, and stigma associated with youth mental health and suicide, emphasizing the importance of raising awareness and developing intervention strategies to tackle the critical issues facing young people.
Blood vessels on black background

Saving lives from cardiovascular diseases in Africa

Professor Derek Yellon from the Hatter Cardiovascular Institute at University College London and Professor Mpiko Ntsekhe from the University of Cape Town discuss the increasing prevalence of cardiovascular diseases (CVD) in Africa and the associated treatment challenges.
An urban wastewater sampling point is located in Pakadjuma, Kinshasa. The surrounding environment is characterised by intense commercial activity, particularly food sales, small-scale trade, and informal waste discharge, which makes this location a strategic sentinel point for pathogen surveillance.

Environmental surveillance as a sentinel for emerging outbreaks: Lessons from mpox in Africa

Here, various academic experts examine research on environmental surveillance as an early warning system for emerging outbreaks, focusing on lessons learned from Mpox in Africa.
Fig. 1. Overview of the HPK nano-bioparticle (NBP) technology. A, Schematic of technology. The HPK linear peptide (graphic) displays each functional domain in a different color. The schematic illustrates the self-assembly of HPK with various therapeutic cargoes into NBPs, which are designed to target tumors in the body. B, Data highlights of NBP technology. The ribbon structure of HPK shows color-coded domains and natural formation as a pentamer (appearing as rings under electron microscopy (EM) that self-assembles into NBPs (appearing as polyhedral under EM) upon exposure to cargo. IV injection in mice results in tumor-selective accumulation and delivery of therapeutic payload, reducing tumor growth.

Nano-bioparticles: Fighting cancer with targeted nanotherapy

Dr LK Medina-Kauwe developed a bioengineered delivery system to treat resistant and metastatic tumors, highlighting the potential of nano-bioparticles to enhance cancer therapy by targeting specific tumor characteristics and overcoming treatment barriers.
Contemporary Spiral Wire Formation with Curved Linear Elements in Teal and Emerald Tones

Canada’s critical minerals research in building its future economy

Mostafa Fayek, Distinguished Professor at the University of Manitoba, discusses the significance of critical minerals (CMs) in modern technology and national security, highlighting their essential role in Canada’s economy and energy transition.
Woman in laboratory, examining new potions for the scientific research at university. Woman is wearing protective mask and protective gloves (Surgical gloves) while working with beakers, test tubes and other lab equipment. Series of images, taken with Nikon D800 and 50mm or 85 mm professional lens, developed from RAW.

3TR Project: Crossing disease borders to reshape European research

By utilising advanced technologies, the 3TR project aims to transform the understanding and treatment of immune-mediated diseases, with its core principles in precision medicine. Principal investigator, Marta E. Alarcon-Riquelme, explains.
A hand with a microplate filled with color samples

Smarter decisions, better outcomes: How a new molecular test improves patient care

Oliver Bathe, Professor of Surgery and Oncology at the University of Calgary and CEO of Qualisure Diagnostics, examines how a new molecular test can lead to smarter decisions and better patient care outcomes in his third article.
Figure 1. Sketch of a selection of tested surface structures with different numbers of ejected atoms in different patterns

Vaporization impacts surface tension

In this article, Prof Dr-Ing. Jörg Volpp from University West, Trollhättan in Sweden, explores how surface tension in pure metals behaves at high temperatures, particularly in the boiling range.

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