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Fig. 1. Overview of the HPK nano-bioparticle (NBP) technology. A, Schematic of technology. The HPK linear peptide (graphic) displays each functional domain in a different color. The schematic illustrates the self-assembly of HPK with various therapeutic cargoes into NBPs, which are designed to target tumors in the body. B, Data highlights of NBP technology. The ribbon structure of HPK shows color-coded domains and natural formation as a pentamer (appearing as rings under electron microscopy (EM) that self-assembles into NBPs (appearing as polyhedral under EM) upon exposure to cargo. IV injection in mice results in tumor-selective accumulation and delivery of therapeutic payload, reducing tumor growth.

Nano-bioparticles: Fighting cancer with targeted nanotherapy

Dr LK Medina-Kauwe developed a bioengineered delivery system to treat resistant and metastatic tumors, highlighting the potential of nano-bioparticles to enhance cancer therapy by targeting specific tumor characteristics and overcoming treatment barriers.

Cedars-Sinai Medical Center

Cedars-Sinai boasts a world-renowned faculty and is ranked among the top ten non-university biomedical research institutions.

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