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Figure 1: Diffusion tensor imaging produces ten 3D volumes highlighting different cytoarchitecture. Selected volumes include: MD- mean diffusivity follows the integrity of cortical layers, layers in the hippocampus and thalamic nuclei. FA- fractional anisotropy provides a measure of white matter health. ClrTDI- Color track density shows local fiber tracks with color indicating local direction of the fibers (Red- left/ right; Green- in/out of plane; Blue top/bottom. Fiber tracking allows one to measure the global and local connectivity in the whole brain. The resolution in the TDI is 5 μm. The inset (1 mm wide) shows a magnified region of hippocampus in which apical dendrites are visible.

3D microscopic whole brain neurodegenerative MRI

This article by G. Allan Johnson, Ph.D., focuses on advanced MRI techniques for studying neurodegenerative diseases, exploring the challenges of screening therapies for conditions like Alzheimer’s and Parkinson’s, and highlighting the promising research conducted at Duke University.

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