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Home Tara M. DeSilva – Cleveland Clinic

    Tara M. DeSilva

    Associate Professor and Vice Chair
    Department of Neurosciences, Cleveland Clinic
    Elize Sturkenboom – van de Wetering

    Contributor's Details

    Phone: +1 216 217 6107
    Email: desilvt@ccf.org
    Website: Visit Website
    Twitter: Follow on Twitter

    Contributor's Articles

    • Fig. 1 White matter hyperintensities (illustrated in blue) in a representative image of the human brain (A) are primarily found near ventricles. The neuronal cell bodies are found mainly in the cortex (gray matter) and myelinated neuronal axons in the white matter (B). Figure created using BioRender.
      What is the link between white matter lesions and neurodegeneration?
    • Figure 1: Immunomodulatory therapies are effective during the relapsing-remitting phase of MS, when immune cells are found in active lesions, but fail to ameliorate progressive decline and irreversible clinical disability. Increased axonal injury correlates with lack of immune cell infiltration but sustained activation of resident CNS glial cells in the progressive phase. These pathological findings are consistent with MRI imaging studies demonstrating virtually no new lesions occurring during progressive MS. Additionally, at the time of MS diagnosis there is evidence of prior lesion activity by MRI imaging supporting that the future development of neuroprotective strategies should be administered in combination with immunomodulatory therapies.
      Targeting the central nervous system: The future of therapeutic strategies for MS
    • Remyelinating versus neuroprotective therapies for multiple sclerosis
    • neurodegeneration
      Neurodegeneration in multiple sclerosis: retinal imaging as a biomarker

    Contributor's Posts

    • Regenerative therapies for multiple sclerosis: Clues from studying normal brain development
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