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Invasive electrical stimulation for stroke treatment

The CorTec Brain Interchange system is a potential tool to improve motor rehabilitation after stroke (Schuettler, 2023). Here, it is sketched how results from studies of other groups are combined to form CorTec’s vision of a new therapy and how first human data was collected to prove the systems therapy capability.
Digitally generated image, perfectly usable for all kinds of topics related to digital innovations, AI, data processing, network security or technology and computer science in general.

Flame system: Computerised cognitive assessment for remote brain health monitoring

Monitoring brain health, particularly cognition, in older adults is increasingly recognised as a significant priority for research, healthcare and broader public health. Find out here about the development and validation of the FLAME System, a computerised cognitive assessment for remote brain health monitoring.
Image: © peterschreiber.media | iStock

A guide for occipital neuralgia patients

Giorgio Pietramaggiori, MD, PhD and Saja Scherer, MD, from the Global Medical Institute, help us to understand occipital neuralgia in this detailed patient guide.
Figure 1: The central nervous system (CNS) is protected from mechanical injury by the skull (A) and from chemical noxious agents by the blood-brain barrier (B, C). The latter consists of the endothelial barrier in most parts of the CNS (B) and the tanycytic barrier in the hypothalamus (C). We develop gene vectors transducing endothelial cells and tanycytes to treat genetic and non-genetic diseases of the brain.

Bridging brain barriers for gene therapy

Reflecting on the challenges in treating brain diseases, this article explores ways to transduce the blood-brain barrier as well as the critical role of tanycytes as a target for gene therapy vectors.

AI healthcare research: Pioneering iSMART Lab

Dr Narges Armanfard, Professor, talks us through the AI healthcare research at McGill University which is spearheading a groundbreaking initiative – the iSMART Lab.
High Energy Consuming Processes in Neurons: Axonal transport Synaptic vesicle recycling, Neurotransmitter release/reuptake, ion pumping, organelle maintenance, protein turnover. therapeutics for neurodegenerative disease

Contribution of oxidative stress to neurodegenerative disease

Paul A. Hyslop, from Arkley BioTek Indianapolis, details an ongoing specific research approach to identify, characterize, and validate physiologically relevant neuronal targets of H2O2 in designing therapeutics for neurodegenerative disease progression.
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Internet-delivered cognitive behavioural therapy

Heather D. Hadjistavropoulos, Hugh C. McCall, and Jill A. B. Price, walk us through internet-delivered cognitive behavioral therapy tailored to public safety personnel.
colourful brain - dementia prevention

Dementia prevention: Raising awareness about dementia and risk reduction

We hear from Dr Anthony J. Levinson, who is part of an academic group developing evidence-based online resources to complement dementia prevention strategies and support care partners.
1: Electrode Model Module 2: Electrode Connector 3: Implant Module 4: Headpiece (Wireless Power Supply of Implant Module) 5: Communication Unit (Wireless Communication with Implant Module) A: Trigger Input B: PC Cable Connector C: Headpiece Cable Connector 6: Personal Computer (PC)

Preparing for a clinical study on implant-enhance stroke rehabilitation

Martin Schuettler, Chief Technology Officer at CorTec GmbH, addresses key questions around the development of the company’s innovative Brain Interchange System to support stroke rehabilitation therapy.
Figure 1. Two routes of brain infection by which SARS-CoV-2 may enter the hypothalamus and infect GnRH neurons. The virus attaches to and enters cells harbouring surface receptors such as ACE2 (black spanner-like symbol) or NRP1 (red cylinder). GnRH neurons exhibit both, which might increase their vulnerability. A. The haematological route, whereby the respiratory virus (white spheres) makes its way through the lungs into the bloodstream (dark red), and thence into the median eminence (ME), a part of the hypothalamus that harbours ”fenestrated” or leaky blood vessels. The virus may affect a number of different cell types locally, including GnRH neurons (green), whose secretory terminals approach the fenestrated vessels, and tanycytes (grey), whose processes control this secretion and also transport other bloodborne hormones and other substances into the brain. Once inside the brain ventricles (V), fluid-filled canals within the brain, the virus can also travel to other areas. B. The olfactory route, whereby the virus enters the olfactory bulb (OB) of the brain directly from the nose across the bony cribriform plate by means of nerve bundles or infected olfactory neurons and other cell types. GnRH neurons, which are born in the nasal epithelium during the embryonic period and migrate into the brain along these nerve bundles to their final positions, still maintain a connection with their birthplace, and could be thus be infected directly or indirectly through olfactory neurons or other cells. GnRH neurons also project to parts of the brain involved in higher functions such as cognition, potentially contributing to long-COVID symptoms such as “brain fog”.

Brain infection by SARS-CoV-2: Lifelong consequences

The WATCH team, founded to elucidate the role played by specialized brain cells called tanycytes in various physiological processes, has been investigating how and where the SARS-CoV-2 virus infects the brain, and some long-term consequences of this neuro-invasion.
Fig. 1 White matter hyperintensities (illustrated in blue) in a representative image of the human brain (A) are primarily found near ventricles. The neuronal cell bodies are found mainly in the cortex (gray matter) and myelinated neuronal axons in the white matter (B). Figure created using BioRender.

What is the link between white matter lesions and neurodegeneration?

Tara M. DeSilva from the Department of Neurosciences, Cleveland Clinic, examines the link between white matter lesions and neurodegeneration.
View of the synapses. Brain connections. Neurons and synapses. Communication and cerebral stimulus. Neural network circuit, degenerative diseases, Parkinson. 3d render

Treatments for ADHD: Can neurotherapies help treat children and adults?

Professor Katya Rubia from the Institute of Psychiatry, Psychology, and Neurosciences at King’s College London discusses the potential of non-invasive brain therapies, including neurofeedback, as treatments for ADHD.
Panther project, brain injury detection

Advanced brain injury detection and protection

The U.S.-based PANTHER program is pioneering a physics-based approach to TBI for quantitatively and deterministically linking the physics of a head insult to the resulting biological injury response. Christian Franck and Alice Lux Fawzi discuss.
Figure 1. A) A test for AI consciousness B) Integrating AI and biological hemispheres with C) a radically new brain-machine-interface that reads and writes from the surface of dissected axonal bundle (e.g., corpus callosum)

AI consciousness and neuroscientifically plausible “seamless” mind-uploading

Masataka Watanabe, Associate Professor at the University of Tokyo’s School of Engineering, examines a test for AI consciousness. He proposes it as part of a scientific approach to deciphering consciousness that leads to “seamless” mind uploading.

Options for stroke survivors: From stroke to conventional therapy

Discovery of novel treatment options for stroke survivors – requirements for implanted systems.
Futuristic laboratory equipment. Brainwave scanning research on computer screens

Exploring neurological & mental brain disorders in Europe

European Brain Council provides a very helpful update on Brain disorders in Europe – neurological and mental alike.
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Psychedelic therapies: The case for a new focus in the EU’s mental health care...

Tadeusz Hawrot, Founder and Executive Director of PAREA, states the case for a new focus in the EU’s mental health care approach, that is the underserved area of psychedelic therapies.
Neuron cells system - 3d rendered image of Neuron cell network on black background. Hologram view interconnected neurons cells with electrical pulses. Conceptual medical image. Glowing synapse. Healthcare concept, brain system

CorTec’s Brain Interchange™ system: Revolutionizing brain therapy with closed-loop neuromodulation

CorTec’s Brain Interchange™ system offers closed-loop neuromodulation, revolutionizing brain therapy by precisely adapting treatment based on individual needs.
Close-up medical syringe with a vaccine, BoNT-A injection

Potential implications of cosmetic BoNT-A use on future treatment options for neuromuscular disorders and...

Given the rise in cosmetic procedures involving BoNT-A, cosmetic physician Dr Mary Dingley discusses the therapeutic implications of antibody-induced resistance on future treatment of various conditions, including post-stroke spacticity and pain disorders.
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Recording and decoding neural signals from the vagus nerve

Dominique M Durand, distinguished Professor of Biomedical Engineering, Case Western Reserve University, Cleveland Ohio, USA, discusses the study of neural signals from the vagus nerve.
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